American Board of Psychiatry and Neurology (ABPN) Practice Exam 2025 - Free ABPN Practice Questions and Study Guide

Naltrexone extended-release injectable suspension is specifically indicated for the treatment of alcohol dependence. This formulation provides a sustained release of the medication, which helps to reduce cravings and decrease the likelihood of relapse for individuals with alcohol use disorder. Naltrexone acts as an opioid antagonist, which means it blocks the euphoric effects of opioids and alcohol, contributing to a reduction in the desire to consume these substances.

In the context of alcohol dependence, naltrexone aids in decreasing the reinforcement of drinking behavior, making it a valuable part of a comprehensive treatment strategy that may include counseling and support groups. Its use is based on clinical studies demonstrating effectiveness in reducing heavy drinking days and improving abstinence rates.

The other disorders mentioned, such as major depressive disorder and generalized anxiety disorder, typically require different classes of medications for treatment, like antidepressants or anxiolytics. Cocaine withdrawal, while it presents its own challenges, is not effectively treated with naltrexone, as it does not address the unique neurobiological mechanisms involved in cocaine dependence and withdrawal. Thus, naltrexone's targeted indication for alcohol dependence makes it the correct answer in this scenario.