American Board of Psychiatry and Neurology (ABPN) Practice Exam 2025 - Free ABPN Practice Questions and Study Guide

Aripiprazole is considered one of the most effective medications for the symptomatic treatment of Tourette's syndrome, particularly due to its atypical antipsychotic properties. It has a favorable side effect profile compared to traditional antipsychotics, which makes it a popular choice in managing the disorder. Aripiprazole works by modulating dopamine activity in the brain, which can help reduce the frequency and severity of tics.

While haloperidol, a conventional antipsychotic, has historically been used for Tourette's syndrome, its side effects, including tardive dyskinesia and other extrapyramidal symptoms, can be limiting for patients. Therefore, aripiprazole offers a more favorable balance of efficacy and tolerability.

Methylphenidate and amphetamines are primarily used to treat attention-deficit/hyperactivity disorder (ADHD) and are not effective for reducing Tourette's symptoms. Although some patients with Tourette’s may also have ADHD, the stimulant medications can sometimes exacerbate tics.

In summary, aripiprazole’s mechanism of action, along with its improved side effect profile compared to older antipsychotics like haloperidol, makes it an effective first-line treatment for