American Board of Psychiatry and Neurology (ABPN) Practice Exam 2025 - Free ABPN Practice Questions and Study Guide

Acquired peripheral neuropathy can result from a variety of conditions and exposures, and each of the options listed has an established link to causing nerve damage. Systemic lupus erythematosus is an autoimmune disorder that can lead to peripheral neuropathy via various mechanisms, including vasculitis and the effects of antibodies. Toluene intoxication is known to cause toxic neuropathy due to prolonged exposure to organic solvents, which can damage peripheral nerves. Similarly, vincristine, a chemotherapeutic agent, is recognized for its neurotoxic side effects, leading to peripheral neuropathy in patients receiving the treatment.

Acetaminophen overdose primarily affects the liver and does not typically lead to peripheral neuropathy. While chronic use of acetaminophen or underlying liver disease can have other neurological implications, the acute toxicity from an overdose is unlikely to directly cause peripheral neuropathy. This distinction highlights why acetaminophen overdose does not fit as a cause of acquired peripheral neuropathy compared to the other options listed.