American Board of Psychiatry and Neurology (ABPN) Practice Exam 2026 - Free ABPN Practice Questions and Study Guide

Peripheral neuropathy can develop as a complication during the treatment for tuberculosis primarily due to the use of isoniazid, a first-line medication for this disease. Isoniazid can lead to a deficiency in vitamin B6 (pyridoxine), which is essential for the proper synthesis of neurotransmitters and the maintenance of nerve health. When vitamin B6 levels decrease, it can result in neuropathic symptoms, including sensory loss, tingling, and numbness, indicative of peripheral neuropathy.

In the context of tuberculosis treatment, patients receiving isoniazid often require additional supplementation with vitamin B6 to prevent this deficiency and its neurological side effects. Recognizing the link between isoniazid and vitamin B6 deficiency is crucial in minimizing the risk of developing peripheral neuropathy in these patients.

While the other conditions listed can cause neuropathy under different circumstances, they are not directly linked to the treatment of tuberculosis or specifically to the use of isoniazid.