American Board of Psychiatry and Neurology (ABPN) Practice Exam 2026 - Free ABPN Practice Questions and Study Guide

Trazodone is an antidepressant that is often prescribed for its sedative properties, particularly in the treatment of major depressive disorder and for insomnia. One of the notable and serious side effects associated with trazodone is priapism, which refers to a prolonged and often painful erection that lasts for several hours and is not related to sexual desire or stimulation. This condition arises due to the drug's effects on serotonin receptors and its influence on blood flow.

Priapism can be a medical emergency, as it can lead to long-term damage if not treated promptly. This side effect is especially significant in understanding the use of trazodone, as it emphasizes the importance of monitoring for potential complications associated with the medication.

Other potential side effects, such as delayed orgasm and retrograde ejaculation, are also relevant but occur less frequently and are typically less severe compared to the risk of priapism. Hence, priapism stands out as the most commonly associated and concerning side effect when considering trazodone therapy.