American Board of Psychiatry and Neurology (ABPN) Practice Exam 2025 - Free ABPN Practice Questions and Study Guide

Question: 1 / 1275

The GABA-A receptor primarily functions as which type of channel?

Sodium channel

Chloride channel

The GABA-A receptor primarily functions as a chloride channel, which is crucial for its role in inhibitory neurotransmission in the central nervous system. When gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, binds to the GABA-A receptor, it causes the channel to open and allows chloride ions to flow into the neuron. This influx of negatively charged chloride ions leads to hyperpolarization of the neuron, making it less likely to fire an action potential.

This mechanism is fundamental to the effects of various anxiolytic and sedative medications, such as benzodiazepines and barbiturates, which enhance GABA's inhibitory action by promoting chloride influx. Understanding this function helps to clarify how GABA-A receptor modulation can impact neuronal excitability and contribute to treatment strategies for anxiety, epilepsy, and other neurological disorders.

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Calcium channel

Potassium channel

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